Fourier Transform Infrared (FTIR) Spectrometer
Records the infrared absorption spectrum of a sample, which acts as a molecular fingerprint. The standard technique for identification of APIs and excipients in pharma QC.
- Pharmaceutical
- Polymers & plastics
- Chemicals
- Forensics
- Food
- Academic research
FTIR calibration procedures
Wavenumber accuracy (polystyrene)
Checks that the FTIR reports absorption bands at the correct wavenumbers, by recording the spectrum of a certified polystyrene film and comparing band positions with reference values.
Open procedureResolution
Checks that the FTIR can resolve close bands, by measuring the depth of the dips between neighbouring polystyrene bands near 2850 and 1583 cm⁻¹.
Open procedureSignal-to-noise
Measures the noise on a '100% line' (two backgrounds ratioed against each other) and converts it into a signal-to-noise ratio to compare with the manufacturer's specification.
Open procedureInstrument qualification (DQ · IQ · OQ · PQ)
- 01
DQ — Design qualification
Defines requirements such as spectral range, resolution, ATR and transmission accessories, library and compliant software, and confirms the selected model meets them.
- 02
IQ — Installation qualification
Confirms correct delivery, installation, environment (humidity), accessories, software and documentation.
- 03
OQ — Operational qualification
Tests wavenumber accuracy and repeatability with polystyrene, resolution, signal-to-noise (100% line noise) and, where relevant, photometric performance.
- 04
PQ — Performance qualification
Shows ongoing fitness for use, typically by a routine polystyrene check and successful identification of known reference materials.
Keep every FTIR in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.