Ion Chromatograph (IC)
Separates charged species (anions, cations, small organic acids and amines) on an ion-exchange column and usually detects them by conductivity. Used in pharma QC for counter-ions, inorganic impurities and ions in water.
- Pharmaceutical
- Power and water utilities
- Environmental
- Food & beverage
- Semiconductor
- Chemicals
IC calibration procedures
Pump flow rate accuracy
Checks that the IC pump delivers the set flow, by weighing water collected over a timed interval.
Open procedureConductivity detector linearity
Checks that the suppressed conductivity response rises in proportion to ion concentration, using a series of chloride (or mixed-anion) standards.
Open procedureInstrument qualification (DQ · IQ · OQ · PQ)
- 01
DQ — Design qualification
Defines needs such as anion and/or cation capability, eluent generation, suppressor type, detection limits and CDS compliance.
- 02
IQ — Installation qualification
Verifies components, serial numbers, utilities, software and that all modules communicate with the CDS.
- 03
OQ — Operational qualification
Tests pump flow accuracy, injection precision, conductivity detector linearity and noise, cell temperature and carry-over.
- 04
PQ — Performance qualification
Runs a representative standard (e.g. a seven-anion mix) to show resolution, precision and sensitivity meet the intended methods.
Keep every IC in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.