LimsPulse
Thermal analysis & ovens

Differential Scanning Calorimeter (DSC)

Measures the heat flowing into or out of a small sample compared with an empty reference pan while both are heated or cooled. It shows melting, crystallisation, glass transitions and polymorphic changes.

  • Pharmaceutical
  • Polymers and plastics
  • Food
  • Materials research
  • Chemicals
Photo of a Differential Scanning Calorimeter (DSC)
Photo: Nick Birse, CC BY-SA 4.0 (cropped), via Wikimedia Commons
CALIBRATION

DSC calibration procedures

Temperature and enthalpy calibration (indium)

Melts a certified indium standard and checks the onset temperature and heat of fusion against the certified values (onset 156.6 °C, ΔH about 28.45 J/g).

Open procedure
QUALIFICATION

Instrument qualification (DQ · IQ · OQ · PQ)

  1. 01

    DQ — Design qualification

    Defines the temperature range, cooling needs, sensitivity, pan types, autosampler and software compliance needs (for example 21 CFR Part 11).

  2. 02

    IQ — Installation qualification

    Confirms the instrument, gas supply, cooling unit and software are installed correctly and documented.

  3. 03

    OQ — Operational qualification

    Verifies temperature and enthalpy accuracy with certified standards such as indium, baseline flatness and heating rate accuracy.

  4. 04

    PQ — Performance qualification

    Shows consistent performance in routine use, for example by a periodic indium check run with the routine method conditions.

In LimsPulse · Calibration Management

Keep every DSC in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.

See how