LimsPulse
Bioanalytical

Capillary electrophoresis system

Separates charged molecules in a thin fused-silica capillary under a high voltage (typically up to 30 kV). Used in biologics QC for size purity (CE-SDS), charge variants (cIEF, CZE) and glycan analysis.

  • Biotechnology
  • Biopharmaceutical
  • Pharmaceutical
  • Genomics
  • Forensic science
  • Academic research
Photo of a Capillary electrophoresis system
Photo: Mark Pellegrini, CC BY-SA 3.0 (cropped), via Wikimedia Commons
CALIBRATION

CE calibration procedures

Temperature and voltage verification

Checks the capillary cartridge temperature and the high-voltage output of the CE system against calibrated tools or the manufacturer's verification kit.

Open procedure
QUALIFICATION

Instrument qualification (DQ · IQ · OQ · PQ)

  1. 01

    DQ

    Define separation modes, detectors, voltage range, temperature control range, autosampler cooling and software compliance needs.

  2. 02

    IQ

    Install, check electrical safety and cooling, install software and record serial numbers and capillary details.

  3. 03

    OQ

    Verify capillary temperature, voltage and current accuracy, injection precision, detector wavelength accuracy, noise and drift.

  4. 04

    PQ

    Run a reference standard by the routine method (for example CE-SDS of a reference antibody) and confirm migration time, resolution and area precision meet set criteria.

In LimsPulse · Calibration Management

Keep every CE in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.

See how