Titration & electrochemistry
Karl Fischer Titrator (Volumetric)
Measures the water content of a sample by titrating it with an iodine-containing Karl Fischer reagent from a motorised burette. The standard method for water in APIs, excipients and many finished products.
- Pharmaceutical
- Chemicals
- Food & beverage
- Petrochemicals
- Cosmetics
PREVENTIVE MAINTENANCE
Maintenance checklist
Daily / each use
- Check drift before use
- Check reagent and solvent levels
- Check septum and joints for leaks
- Check for crystals or deposits at the burette tip
Weekly
- Clean the titration cell and electrode
- Replace the septum if it has been pierced many times
- Check molecular sieve colour or condition
Monthly / quarterly
- Regenerate or replace molecular sieve
- Inspect burette tubing and valves for leaks or air bubbles
- Clean platinum pins with a mild abrasive or as advised by the supplier if response is sluggish
Six-monthly / annual
- Burette accuracy check (gravimetric)
- Preventive maintenance by a trained engineer
- Software and audit-trail review
SAFETY
Safety precautions
Before you work on the KF titrator (volumetric)
- KF reagents and methanol are toxic and flammable: work in a fume hood away from ignition sources.
- Wear gloves, safety glasses and a lab coat when handling reagents and emptying the cell.
- Collect spent KF solvent in a labelled, closed halogen-free organic waste container, or as directed by your site waste procedure.
- Do not mix KF waste with strong oxidisers or acids.
In LimsPulse · Calibration Management
Keep every KF titrator (volumetric) in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.