Dosage-form testing
Dissolution Test Apparatus
Measures how fast and how completely the drug is released from a tablet or capsule into a liquid medium held at body temperature. A key quality and release test for oral solid dosage forms.
- Pharmaceutical
- Generic drug development
- Nutraceuticals and dietary supplements
- Veterinary medicines
- Contract research and testing labs
PREVENTIVE MAINTENANCE
Maintenance checklist
Each use
- Check bath level and temperature
- Inspect paddles, baskets and vessels
- Clean vessels, shafts and baskets after use
- Record any abnormal noise or vibration
Weekly
- Clean the bath and change the water (use an algicide only if it does not leave residues)
- Check vessel centring rings and plate fixings
- Clean auto-sampler lines and replace in-line filters if used
Monthly / quarterly
- Check basket mesh for damage or corrosion and replace worn baskets
- Check drive belt and shaft bearings for noise
- Verify speed and temperature with calibrated tools
Six-monthly / annual
- Full mechanical calibration of all positions
- Performance verification test where required by your SOP
- Preventive maintenance by a trained engineer
SAFETY
Safety precautions
Before you work on the Dissolution tester
- Keep hands and loose clothing away from rotating shafts; stop rotation before adjusting anything in the vessel.
- The bath contains electrical heaters: never run it without enough water and keep the electrical parts dry.
- Some media contain surfactants, acids or enzymes; read the safety data sheet and wear gloves and safety glasses.
- Handle glass vessels with care; chipped vessels can cut and must be replaced.
- Wipe up spills promptly; wet floors around the bath are a slip hazard.
In LimsPulse · Calibration Management
Keep every Dissolution tester in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.