LimsPulse
General lab & storage

Stability chamber

A cabinet or walk-in room that holds samples at a controlled temperature and relative humidity for months or years, so that the shelf life of a drug product can be established under ICH storage conditions.

  • Pharmaceutical
  • Biotech
  • Medical devices
  • Cosmetics
  • Food & nutraceuticals
  • Packaging
Photo of a Stability chamber
Photo: Encik Tekateki, CC BY-SA 4.0 (cropped), via Wikimedia Commons
TROUBLESHOOTING

Common problems, causes and fixes

RH below set point
Likely causes
  • • Humidifier water supply empty
  • • Scaled or failed humidifier element
  • • Door gasket leaking
What to do
  • • Refill with purified water and check the supply line
  • • Descale or replace the humidifier element
  • • Replace the door gasket
RH above set point
Likely causes
  • • Dehumidifying coil iced or not cooling
  • • Wet samples or open water container inside
  • • Blocked condensate drain
What to do
  • • Defrost and check the refrigeration system
  • • Remove the source of moisture
  • • Clear the drain
Temperature slowly drifting high
Likely causes
  • • Dirty condenser coil
  • • Low refrigerant
  • • Room too warm around the chamber
What to do
  • • Clean the condenser
  • • Call service to check refrigerant
  • • Improve room ventilation or air conditioning
Display and monitoring system disagree
Likely causes
  • • Sensor drift
  • • Probes in different positions
  • • Monitoring probe out of calibration
What to do
  • • Calibrate both sensors against a reference
  • • Check probe locations against the mapping report
  • • Recalibrate or replace the drifting probe
Frequent short alarms
Likely causes
  • • Frequent or long door openings
  • • Alarm delay set too short
  • • Controller tuning poor
What to do
  • • Plan sample pulls together
  • • Set a justified alarm delay in the SOP
  • • Ask service to re-tune the controller
Uneven conditions between shelves
Likely causes
  • • Overloading or blocked air paths
  • • Fan fault
What to do
  • • Reduce load and keep space around packs
  • • Check and repair fans; re-map if needed
In LimsPulse · Calibration Management

Keep every Stability chamber in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.

See how