Dosage-form testing
Franz Diffusion Cell (Vertical Diffusion Cell)
A two-chamber glass cell used to measure how fast drug is released from creams, gels and ointments, or permeates through skin. Drug passes through a membrane into a stirred receptor medium that is sampled over time.
- Pharmaceutical (topicals and transdermals)
- Cosmetics
- Research and academia
PREVENTIVE MAINTENANCE
Maintenance checklist
Each use
- Clean cells, stir bars and clamps
- Inspect glass for chips at the joint faces
Monthly
- Check temperature of each position
- Check stirrer speed
Annual
- Calibrate thermometer / temperature probe and stirrer speed
- Verify receptor volumes and orifice diameters
SAFETY
Safety precautions
Before you work on the Franz cell
- Handle glass cells carefully; chipped joints cut and leak.
- Use gloves when handling potent topical drugs and receptor media with solvents.
- Excised skin is biological material; follow biosafety rules.
In LimsPulse · Calibration Management
Keep every Franz cell in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.