Dosage-form testing
Liquid Particle Counter (Light Obscuration)
Counts and sizes sub-visible particles in injections by passing the liquid through a narrow light beam. Each particle casts a shadow whose size gives the particle size. Used for the USP <788> particulate matter test.
- Pharmaceutical (parenterals)
- Biotech
- Medical devices
- Industrial fluids
PREVENTIVE MAINTENANCE
Maintenance checklist
Each use
- Flush the sensor with particle-free water
- Run a water blank
- Check syringe for air
Monthly
- Clean sensor with a mild detergent as per the manual
- Check sample volume accuracy
Annual (or as per chapter)
- Sizing calibration with certified spheres
- Sensor resolution and counting accuracy checks
- Sample volume accuracy and flow rate verification
SAFETY
Safety precautions
Before you work on the Liquid particle counter
- The sensor contains a laser diode; do not open it.
- Handle glass ampoules and broken glass carefully.
- Cytotoxic or potent injections must be tested in a suitable containment cabinet.
In LimsPulse · Calibration Management
Keep every Liquid particle counter in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.