Titration & electrochemistry
Total Organic Carbon (TOC) Analyser
Oxidises organic compounds in water to carbon dioxide and measures the CO₂ formed to give the total organic carbon content. The standard test for organic contamination in purified water and water for injections.
- Pharmaceutical
- Biotech
- Semiconductors
- Power generation
- Environmental
- Drinking water
Follow your site SOP
This is a typical operating sequence for learning. Your instrument model and approved SOP take precedence.
STAGE 1
Before you start
- 1Check the analyser's calibration and last system suitability are within date.
- 2Check reagent levels (acid, oxidiser) and gas supply if used.
- 3Use TOC-certified (low-carbon) vials and caps; do not touch the inside of vials or caps.
- Wear powder-free gloves and avoid solvents or perfumes near the samples: they add organic carbon.
STAGE 2
System suitability
- 1Analyse the reagent water blank, the 0.50 mg/L carbon sucrose standard and the 0.50 mg/L carbon 1,4-benzoquinone solution.
- 2Calculate the response efficiency and check it is within 85–115%.
STAGE 3
Sample analysis
- 1Collect samples in clean TOC vials, filling them with no headspace if required by the SOP.
- 2Analyse promptly, or store as validated (for example refrigerated for a defined time).
- 3Run samples, with a blank and a check standard as required by the sequence.
- 4Compare each sample result with the limit response.
- Avoid air bubbles and headspace: CO₂ and organic vapours from air can change the result.
STAGE 4
Shutdown
- 1Flush the system with reagent water as recommended by the supplier.
- 2Put the instrument in standby and complete the usage log.
In LimsPulse · Calibration Management
Keep every TOC analyser in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.