Total Organic Carbon (TOC) Analyser
Oxidises organic compounds in water to carbon dioxide and measures the CO₂ formed to give the total organic carbon content. The standard test for organic contamination in purified water and water for injections.
- Pharmaceutical
- Biotech
- Semiconductors
- Power generation
- Environmental
- Drinking water
TOC analyser calibration procedures
System suitability (sucrose / benzoquinone)
Compares the response to an easy-to-oxidise compound (sucrose) with a hard-to-oxidise compound (1,4-benzoquinone) at the same carbon level to prove the analyser oxidises organics efficiently.
Open procedureCalibration standards
Calibrates the analyser's response against standards of known carbon concentration (for example potassium hydrogen phthalate or sucrose) and checks it with an independent standard.
Open procedureInstrument qualification (DQ · IQ · OQ · PQ)
- 01
DQ — Design qualification
Defines the requirements: offline or online use, range (for example ppb levels), oxidation and detection type, compliance with USP <643> and data integrity features.
- 02
IQ — Installation qualification
Confirms installation, utilities (power, gas, sample lines), serial numbers, software version and documentation.
- 03
OQ — Operational qualification
Verifies calibration accuracy, linearity, repeatability, system suitability with sucrose and benzoquinone, and limit of detection.
- 04
PQ — Performance qualification
Shows routine performance over time, for example passing system suitability and stable blanks; for online units, comparison with offline grab samples.
Keep every TOC analyser in control: usage logs, calibration and maintenance schedules, and automatic blocking of overdue instruments.